HEALTH – THE BRAIN – ALZHEIMER’S & DEMENTIA – IRON


1 RESEARCH ARTICLE


DEMENTIA IS ASSOCIATED WITH IRON-DEFICIENCY ANEMIA IN FEMALES – 2014


Chung SD1, Sheu JJ2, Kao LT3, Lin HC4, Kang JH
INTRODUCTION:
– Cognitive derangement and neurological symptoms are observed in patients with anemia
– Although it is still controversial, a few studies suggested that anemia may increase the risk of dementia
AIM:
– Explore the association between iron-deficiency anemia (IDA) and dementia in a population-based case-control study
METHOD:
(1) We retrieved our study sample from the Taiwan Longitudinal Health Insurance Database 2000
(2) We extracted 8300 subjects with a diagnosis of dementia and 8300 age- and gender-matched controls
RESULTS:
(1) Significant difference in the prevalence of prior IDA between cases and controls (6.0% vs. 3.8%)
(2) Adjustment made for income, geographic location, urbanization level, hyperlipidemia, diabetes, hypertension, alcohol abuse
(3) Among female subjects, the adjusted OR of prior IDA for cases was as high as 2.00 (95% CI: 1.42-2.80) compared to controls
(4) However, in men-no increased odds of prior IDA were observed, compared to controls.
CONCLUSION:
– Women with dementia had a higher prevalence of prior IDA, compared to controls


 

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