HEALTH – THE BRAIN – ALZHEIMER’S/DEMENTIA – OXIDATIVE STRESS/METABOLIC SYNDROME


1 RESEARCH ARTICLE


ALZHEIMER’S & METABOLIC SYNDROME: A LINK FROM OXIDATIVE STRESS AND INFLAMMATION TO NEURODEGENERATION – 2017


– There is a strong relation between oxidative stress, metabolic syndrome (MetS) and AD
– The high levels of circulating fats and glucose imbalances amplify lipid peroxidation (cell damage) that gradually diminishes the antioxidant systems, causing high levels of oxidative metabolism that affects cell structure, leading to neuronal damage
– Accumulating evidence suggests that AD is closely related to a dysfunction of both insulin signaling and glucose metabolism in the brain, leading to an insulin-resistant brain state
– Four drugs are currently used for this pathology: Three FDA-approved cholinesterase inhibitors and one NMDA receptor antagonist
– However, wide varieties of antioxidants are promissory to delay or prevent the symptoms of AD and may help in treating the disease
– The term inflammaging characterizes a widely accepted paradigm that aging is accompanied by a low-grade chronic up-regulation of certain pro-inflammatory responses in the absence of overt infection, and is a highly significant risk factor for both morbidity and mortality in the elderly


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