HEALTH – OSTEOPOROSIS – DEMENTIA


1 RESEARCH ARTICLE


INCREASED RISK OF DEMENTIA IN PATIENTS WITH OSTEOPOROSIS – 2014


Kuang-Hsi Chang, Chi-Jung Chung, Cheng-Li Lin, Fung-Chang Sung, Trong-Neng Wu, Chia-Hung Kao
METHODS
– Taiwan’s National Health Insurance Research Database (NHIRD)
– 23,941 patients with osteoporosis from 2000 to 2010 and 47,579 nonosteoporosis control patients
RESULTS
(1) Osteoporosis patients exhibited 1.46-fold and 1.39-fold higher risk of dementia and Alzheimer’s disease, respectively, compared with the matched nonosteoporosis patients
(2) Increased risk of dementia in both men and women with osteoporosis
(3) The osteoporosis patients receiving bisphosphonate treatment or estrogen supplementation were associated with significantly lower risk of dementia compared with the osteoporosis patients who did not receive any treatment
CONCLUSIONS
(1) Overall, our results suggest higher risks of dementia in osteoporosis patients than in nonosteoporosis patients
(2) Osteoporosis could thus be considered an early risk factor for dementia
(3) Future large-scale double-blind randomized clinical trials are required to clarify the role of medication in osteoporosis-related dementia


 

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