SLEEP – TESTOSTERONE LEVELS IN MEN – AGING


SLEEP DURATION & DISTURBANCES WERE ASSOCIATED WITH TESTOSTERONE LEVEL, MUSCLE MASS & MUSCLE STRENGTH IN OLDER MEN – 2015


Auyeung TW1, Kwok T2, Leung J3, Lee JS2, Ohlsson C4, Vandenput L4, Wing YK5, Woo J2.
BACKGROUND
– Testosterone level follows a circadian rhythm
– Examine the relationship of sleep duration and disturbances to testosterone level, muscle mass, muscle strength, and walking speed
PARTICIPANTS AND METHODS
– 1274 community-dwelling men older than 65 years of age
RESULTS
(1) Testosterone increased with increasing sleep duration up to 9.9 hrs, after which it decreased, giving rise to an inverted U-shaped relationship
(2) A similar inverted U-shaped relationship occurred between sleep duration and muscle mass and function
(3) Earlier go-to-bed time, despite being associated with a higher testosterone level, was associated with weaker grip strength
(4) Earlier wake-up time was associated with higher muscle mass but neither grip strength nor walking speed
(5) Neither prolonged sleep latency nor insomnia was associated with testosterone levels
(6) However, prolonged sleep latency was associated with lower muscle mass, weaker grip strength, and slower walking speed
(7) Insomnia, on the other hand was associated with weaker grip strength and slower walking speed but not muscle mass
CONCLUSIONS
(1) Sleep duration and disturbances can affect testosterone level, muscle mass, and its function
(2) Whether optimization of sleep can ameliorate age-associated decline in sex hormone and muscle performance warrants further studies


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