1 RESEARCH ARTICLE
Pejovic S, Basta M, Vgontzas AN, Kritikou I, Shaffer ML, Tsaoussoglou M, Stiffler D, Stefanakis Z, Bixler EO, Chrousos GP.
– One workweek of mild sleep restriction adversely impacts sleepiness, performance, and proinflammatory cytokines
– Many individuals try to overcome these adverse effects by extending their sleep on weekends
– 30 young men and women (24.7 ± 3.5 yr)
– Sleep laboratory experiment of 13 nights [4 baseline nights (8 h/night), followed by 6 sleep restriction nights (6 h/night) and 3 recovery nights (10 h/night)]
(1) Serial 24-h IL-6 plasma levels increased significantly during sleep restriction and returned to baseline after recovery sleep
(2) Serial 24-h cortisol levels during restriction did not change compared with baseline, but after recovery they were significantly lower
(3) Subjective and objective sleepiness increased significantly after restriction and returned to baseline after recovery
(4) In contrast, performance deteriorated significantly after restriction and did not improve after recovery
– Extended recovery sleep over the weekend reverses the impact of one work week of mild sleep restriction on daytime sleepiness, fatigue, and IL-6 levels, reduces cortisol levels, but does not correct performance deficits.