HEALTH – T2 DIABETES – OSTEOARTHRITIS


1 RESEARCH ARTICLE


DIABETES IS A RISK FACTOR FOR KNEE OSTEOARTHRITIS PROGRESSION – 2015


Florent Eymard, Xavier Chevalier et al; Osteoarthritis and Cartilage
PURPOSE
Recent studies have suggested metabolic factors (obesity, diabetes, hypertension, dyslipidemia) and their clustering in metabolic syndrome (MetS) might be involved in the pathophysiology of knee osteoarthritis (OA)
METHODS
– 559 patients older than 50 yrs with symptomatic knee OA were recruited for the placebo arm of the SEKOIA trial
– The presence of diabetes, hypertension and dyslipidemia was determined at baseline interview
– BMI was calculated, obesity was considered >30 kg/m(2)
– MetS was defined by the sum of metabolic factors ≥3
– Minimal medial tibiofemoral joint space on plain radiographs was measured by an automated method at baseline and then annually for up to 3 yrs
– The mean age of patients was 62.8 [62.2-63.4] years; 392 were women
– A total of 43.8% were obese, 6.6% had type 2 diabetes, 45.1% hypertension, 27.6% dyslipidemia and 13.6% MetS
RESULTS
(1) Mean annualised JSN was greater for patients with T2D than without diabetes (0.26 [-0.35 – -0.17] vs. 0.14 [-0.16 – -0.12] mm)
(2) This association remained significant after adjustment for sex, age, BMI, hypertension and dyslipidemia (p=0.018)
(3) In subgroup analysis, type 2 diabetes was a significant predictor of JSN in males but not females
(4) The other metabolic factors and MetS were not associated with annualised JSN
CONCLUSION
Type 2 diabetes was a predictor of joint space reduction in men with established knee OA
– No relationships were found between MetS or other metabolic factors and radiographic progression


 

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