4 RESEARCH ARTICLES + 1 GRAPHIC – CLICK ON IMAGE TO ENLARGE
Jacqueline K. Dawson,Christina M. Dieli-Conwright et al
– Prostate cancer patients on androgen deprivation therapy (ADT) experience adverse effects such as lean mass loss, known as sarcopenia, fat gain, and changes in cardiometabolic factors that increase risk of metabolic syndrome (MetS)
– Resistance training can increase lean mass, reduce body fat, and improve physical function and quality of life, but no exercise interventions in prostate cancer patients on ADT have concomitantly improved body composition and MetS
– This pilot trial investigated 12 weeks of resistance training on body composition and MetS changes in prostate cancer patients on ADT
– An exploratory aim examined if a combined approach of training and protein supplementation would elicit greater changes in body composition
– 32 Prostate cancer patients on ADT were randomized to:
A) resistance training and protein supplementation (TRAINPRO)
B) resistance training (TRAIN)
C) protein supplementation (PRO)
D) control stretching (STRETCH)
– Exercise groups (EXE = TRAINPRO, TRAIN) performed supervised exercise 3 days per week for 12 weeks
– TRAINPRO and PRO received 50 g⋅day− 1 of whey protein
– Non-exercise groups (NoEXE = PRO, STRETCH) performed a home-based stretching program
– 32 participated in the intervention (EXE n = 13; NoEXE n = 19)
– At baseline, 43.8% of participants were sarcopenic and 40.6% met the criteria for MetS
– Post-intervention, EXE significantly improved lean mass, sarcopenia prevalence, body fat %, strength, and prostate cancer-specific quality of life compared to NoEXE
– No significant differences were observed between groups for physical function or MetS-related variables except waist circumference
– The primary outcome was change in lean mass assessed through dual energy x-ray absorptiometry
– Secondary outcomes examined changes in sarcopenia, assessed through appendicular skeletal mass (ASM) index (kg/m2), body fat %, strength, physical function, quality of life, MetS score and the MetS components of waist circumference, blood pressure, glucose, high-density lipoprotein-cholesterol, and triglyceride levels
– A 12-week resistance training intervention effectively improved sarcopenia, body fat %, strength and quality of life in hypogonadal prostate cancer patients
– It did not change MetS or physical function
– PRO did not offer additional benefit in improving body composition
NOTE: Need to know the total protein consumed per day
Preethi Srikanthan,MD, MSa, , ,Tamara B. Horwich,MD, MSb, Chi Hong Tseng,PhDc
– We evaluated the relation between components of body composition and mortality in patients with cardiovascular disease (CVD).
– Body composition data from the National Health and Nutrition Examination Survey 1999 to 2004 was linked to total and CVD mortality data 1999 to 2006 in 6,451 patients with CVD
– Subjects were stratified into 4 groups (low muscle/low fat mass, low muscle/high fat mass, high muscle/low fat mass, and high muscle/high fat mass)
– The high muscle/low fat mass group had a lower risk of CVD and total mortality
Hagstrom AD1,2, Marshall PW3, Lonsdale C4, Papalia S5, Cheema BS6,7, Toben C8, Baune BT9, Fiatarone Singh MA10,11, Green S12,13.
– Determine the effects of resistance training (RT) on markers of inflammation and immune function in breast cancer survivors.
– 39 breast cancer survivors were randomly assigned to a RT (n = 20) or control (n = 19) group.
– RT performed supervized exercise three times per week.
– Natural killer cell (NK) and natural killer T-cell (NKT) function, and markers of inflammation (serum TNF-α, IL-6, IL-10, and CRP) measured before and after training
(1) Significant reduction, and large associated ESs, in RT group compared to control for change in NK cell expression of TNF-α and NKT cell expression of TNF-α
(2) No differences were observed in any serum marker.
(3) Significant improvements in all measurements of strength were found in RT compared to control
– RT has a beneficial effect on NK and NKT cell expression of TNF-α
– This indicates RT may be beneficial in improving inflammatory profile in breast cancer survivors
Hagstrom AD1,2, Marshall PW2, Lonsdale C3, Cheema BS2,4, Fiatarone Singh MA5,6, Green S2,7.
– Evaluate the benefits of resistance training (RT) on quality of life (QOL) and fatigue in breast cancer survivors as an adjunct to usual care.
– 39 women who had survived breast cancer [mean age (y) 51.9 ± 8.8; time since diagnosis (m) 11.6 ± 13.2].
– The experimental group received supervised RT 3 days per week in a university clinic for 16 weeks.
– Perceptions of Fatigue and Quality of Life improved significantly in the RT group compared to controls